Planning minister Matthew Guy said the amendment will inject millions into the local economy, create jobs and provide a significant boost to associated supply chain industries.
"This is a fantastic outcome for the Shire of Cardinia and demonstrates that business and the local community can have confidence in Victoria's planning system to drive economic growth and productivity,” Mr Guy said.
"Bringing new jobs to growth areas is important for the future sustainability of Melbourne, so this investment will be a great shot in the arm to the economy of the south east.”
The abattoir is one of the largest employers in the Cardina growth area and is strategically located close to major infrastructure, including the recently announced Koo Wee Rup bypass.
Member for Eastern Victoria Edward O'Donohue said today's announcement is a significant advancement for growth and productivity for the Pakenham region.
"This is an important announcement for the creation of jobs in the Pakenham and south-east growth corridor and, importantly, creates a bright future for one of the long established and most significant employers in the region," Mr O'Donohue said.